DOUBLE STRIKE APPROACH FOR TUMOR ATTACK: ENGINEERING T CELLS USING A CD40L:CD28 CHIMERIC CO-STIMULATORY SWITCH PROTEIN FOR ENHANCED TUMOR TARGETING IN ADOPTIVE CELL THERAPY

Activation of co-stimulatory pathways in cytotoxic T lymphocytes expressing chimeric antigen receptors (CARs) have proven to boost effector activity, tumor rejection and long-term T cell persistence.When using antigen-specific T cell receptors (TCR) instead of CARs, the lack of co-stimulatory signals hampers robust antitumoral response, hence limit

Rapid cooling after harvest, and continuing protection from heat during transit and marketing, are essential to color block iphone case avoid fruit shriveling and quality deterioration of sweet cherries.Delays of four hours or more between harvesting and cooling were particularly damaging, according to tests at Davis.Rapid cooling by forced air was

This research color block iphone case introduces a unique multiple choice exam design to observe and measure the degree to which students copy answers from their peers.Using data collected from the exam, an empirical experiment is conducted to determine whether random seat assignment deters cheating relative to a control group of students allowed t